Wrist Pain can be caused by injuries to the wrist joint, including ligaments, bones, the connective tissue around the wrist, or it could be caused by disease such as Osteoarthritis, and Rheumatoid Arthritis are most common. Carpel Tunnel Syndrome can also cause wrist pain. This is due to overuse and repetitive motion in the wrist. These symptoms are usually tingling and cramping in the hand. Sports-related injuries to the wrist are sprains and fractures.